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no-repeat center/2rem;box-shadow:-0.4rem 0 0.6rem -0.3rem rgba(0,0,0,0.1)}.search-form .search-input .clear-btn.active{display:inline-block}.search-form .search-input .clear-btn:focus{box-shadow:0 0 3px #3E94CF,0 0 7px #3E94CF;outline:none;outline-offset:-0.7rem}.search-form .search-input-trigger{display:none}.search-form .search-links-wrapper{display:-webkit-box;display:flex;-webkit-box-orient:horizontal;-webkit-box-direction:normal;flex-direction:row;-webkit-box-pack:justify;justify-content:space-between;-webkit-box-align:baseline;align-items:baseline}@media screen and (min-width:1020px){.search-form .search-links-wrapper{float:left;width:760px;padding:0 2rem}}.search-form .search-links-wrapper .search-links{font-size:1.4rem;display:inline-block;clear:left}@media screen and (max-width:1019px){.search-form .search-links-wrapper .search-links{margin-left:0;padding-left:0}}.search-form .search-links-wrapper .search-links .search-input-link{color:#0071bc;margin-top:.5rem;margin-right:1rem;display:inline-block}.search-form .search-links-wrapper .search-links .search-input-link.hidden{display:none}.search-form .search-links-wrapper .user-guide-link{font-size:1.4rem;display:inline-block}.search-form .search-links-wrapper .user-guide-link>a:active,.search-form .search-links-wrapper .user-guide-link>a:visited{color:#0071bc}@media screen and (max-width:1023px){.search-form .search-links-wrapper .user-guide-link>a{display:none}}.search-form.content-page-layout{border-bottom:1px solid rgba(0,0,0,0.1)}@media screen and (max-width:376px){.search-form.content-page-layout.search-form .pubmed-logo{margin:.5rem auto}}@media screen and (max-width:759px){.search-form.content-page-layout>.inner-wrap{padding-bottom:.7rem}}@media screen and (max-width:759px){.search-form.content-page-layout .search-input{display:none}.search-form.content-page-layout .search-input.active{display:block}}@media screen and (max-width:759px){.search-form.content-page-layout .search-links-wrapper{-webkit-box-pack:center;justify-content:center;padding-top:.5rem}.search-form.content-page-layout .search-links-wrapper .search-links{margin-left:-3px;padding-right:0}.search-form.content-page-layout .search-links-wrapper .search-links .search-input-link{margin-right:.7rem}.search-form.content-page-layout .search-links-wrapper .search-links .search-input-link:last-of-type{margin-right:0}}.search-form.content-page-layout .back-to-search{display:none;position:absolute;left:.8rem;top:2rem;width:4.4rem;height:4.4rem;background:url("data:image/svg+xml;base64,PHN2ZyB2ZXJzaW9uPSIxLjEiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyIgdmlld0JveD0iMCAwIDQ3Ny4xNzUgNDc3LjE3NSI+CjxnPgoJPHBhdGggZmlsbD0iIzQ5NDQ0MCIgZD0iTTE0NS4xODgsMjM4LjU3NWwyMTUuNS0yMTUuNWM1LjMtNS4zLDUuMy0xMy44LDAtMTkuMXMtMTMuOC01LjMtMTkuMSwwbC0yMjUuMSwyMjUuMWMtNS4zLDUuMy01LjMsMTMuOCwwLDE5LjFsMjI1LjEsMjI1IGMyLjYsMi42LDYuMSw0LDkuNSw0czYuOS0xLjMsOS41LTRjNS4zLTUuMyw1LjMtMTMuOCwwLTE5LjFMMTQ1LjE4OCwyMzguNTc1eiIvPgo8L2c+Cjwvc3ZnPgo=") no-repeat center/3.2rem}@media screen and (max-width:759px){.search-form.content-page-layout .back-to-search{display:inline-block}}.search-form.content-page-layout .search-input-trigger{display:none;position:absolute;right:1.2rem;top:2rem;width:4.4rem;height:4.4rem;background:url("data:image/svg+xml;base64,PHN2ZyB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHZpZXdCb3g9IjAgMCAxMDAgMTA0IiB3aWR0aD0iMTAwcHgiIGhlaWdodD0iMTA0cHgiPgogIDxwYXRoIGZpbGw9IiM0OTQ0NDAiIGQ9Ik0gNDAuOTUxMTcyLC03LjUyNTU2MzJlLTQgQSA0MC45NDk5MTUsNDAuODE1NTYxIDAgMCAwIDAsNDAuODEzNjk3IDQwLjk0OTkxNSw0MC44MTU1NjEgMCAwIDAgNDAuOTUxMTcyLDgxLjYzMDEwNyA0MC45NDk5MTUsNDAuODE1NTYxIDAgMCAwIDY1LjIwODk4NCw3My42Mzk4NjcgTCA5NC44NjEzMywxMDMuNDg1NTggYyAyLjMxMjk5LDEuOTg3MiA2LjU4OTM0LC0yLjI1NTQxIDQuNjQ2NDgsLTQuNjkxNDEzIEwgNzAuMDg5ODQ0LDY5LjQ3MTg5NyBBIDQwLjk0OTkxNSw0MC44MTU1NjEgMCAwIDAgODEuOTAwMzkxLDQwLjgxMzY5NyA0MC45NDk5MTUsNDAuODE1NTYxIDAgMCAwIDQwLjk1MTE3MiwtNy41MjU1NjMyZS00IFogbSAwLDQuMzMzOTc5OTU2MzIgQSAzNi42MDA3MzYsMzYuNDgwNjUyIDAgMCAxIDc3LjU1MjczNCw0MC44MTM2OTcgMzYuNjAwNzM2LDM2LjQ4MDY1MiAwIDAgMSA0MC45NTExNzIsNzcuMjk0MTY3IDM2LjYwMDczNiwzNi40ODA2NTIgMCAwIDEgNC4zNDk2MDksNDAuODEzNjk3IDM2LjYwMDczNiwzNi40ODA2NTIgMCAwIDEgNDAuOTUxMTcyLDQuMzMzMjI3NCBaIi8+Cjwvc3ZnPgo=") no-repeat center/2.8rem;-webkit-transition:background-size 0.3s;transition:background-size 0.3s}.search-form.content-page-layout .search-input-trigger::after{content:'';position:absolute;left:0;right:0;top:0;bottom:0;background:url("data:image/svg+xml;base64,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") no-repeat -0.3rem center/0;-webkit-transition:background-size 0.3s;transition:background-size 0.3s}@media screen and (min-width:481px){.search-form.content-page-layout .search-input-trigger{right:2rem}.search-form.content-page-layout .search-input-trigger::after{background-position:center}}.search-form.content-page-layout .search-input-trigger.active{background-size:0}.search-form.content-page-layout .search-input-trigger.active::after{background-size:3.2rem}@media screen and (max-width:759px){.search-form.content-page-layout .search-input-trigger{display:block}}@media screen and (max-width:1019px){.filters-field{display:none}}@media screen and (max-width:1019px){.filters-field .choice-group-wrapper{padding:0 2rem}}.filters-field .choice-group-wrapper .choice-group{margin-bottom:2rem}.filters-field .choice-group-wrapper .choice-group>.title{font-family:BlinkMacSystemFont,-apple-system,"Segoe UI","Roboto","Oxygen","Ubuntu","Cantarell","Fira Sans","Droid Sans","Helvetica 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.choice-group>.items .dropdown{right:0;left:auto;margin-top:1.5rem;padding:1.2rem 1.6rem 1.6rem;z-index:1000;right:auto;left:0;margin-left:-1rem;margin-top:1rem;width:32rem}@media screen and (min-width:760px) and (max-width:1019px){.filters-field .choice-group-wrapper .choice-group>.items .dropdown{margin-top:1.4rem;padding:1rem 1.2rem 1.2rem}}@media screen and (max-width:759px){.filters-field .choice-group-wrapper .choice-group>.items .dropdown{margin-top:0.3rem}}.filters-field .choice-group-wrapper .choice-group>.items .dropdown::before{content:'';display:block;position:absolute;right:0.9rem;bottom:100%;width:1.2rem;height:1rem;background:url("data:image/svg+xml;base64,PHN2ZyB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHdpZHRoPSIxMCIgaGVpZ2h0PSIxMCI+CiAgPHBvbHlnb24gZmlsbD0nI2Q5ZDlkOScgcG9pbnRzPScwLDkgNSw0IDEwLDkgMTAsMTAgMCwxMCcvPgogIDxwb2x5Z29uIGZpbGw9JyNmZmYnIHBvaW50cz0nMCwxMCA1LDUgMTAsMTAnLz4KPC9zdmc+Cg==") no-repeat center bottom/1.2rem}@media screen and (min-width:760px) and (max-width:1019px){.filters-field .choice-group-wrapper .choice-group>.items .dropdown::before{right:0.8rem}}.filters-field .choice-group-wrapper .choice-group>.items .dropdown.flipped{bottom:100%;top:auto}.filters-field .choice-group-wrapper .choice-group>.items .dropdown.flipped::before{bottom:auto;top:100%;-webkit-transform:rotate(180deg);transform:rotate(180deg)}.filters-field .choice-group-wrapper .choice-group>.items .dropdown>.title{font-family:BlinkMacSystemFont,-apple-system,"Segoe UI","Roboto","Oxygen","Ubuntu","Cantarell","Fira Sans","Droid Sans","Helvetica Neue",sans-serif;font-weight:300;font-size:1.6rem;text-transform:lowercase;font-variant:small-caps;line-height:2rem;margin:0 0 1.3rem}@media screen and (min-width:760px) and (max-width:1019px){.filters-field .choice-group-wrapper .choice-group>.items .dropdown>.title{margin:0 0 1rem;text-align:left}}.filters-field .choice-group-wrapper .choice-group>.items .dropdown>.content{white-space:nowrap}.filters-field .choice-group-wrapper .choice-group>.items .dropdown::before{right:unset;left:1rem}.filters-field .choice-group-wrapper .choice-group>.items .dropdown>.title{text-align:left;line-height:none;margin:auto;color:#5b616b}.filters-field .choice-group-wrapper .choice-group>.items .dropdown>.content{display:-webkit-box;display:flex;-webkit-box-orient:vertical;-webkit-box-direction:normal;flex-direction:column;padding-left:1.5rem;text-align:left}.filters-field .choice-group-wrapper .choice-group>.items .dropdown>.content>ul{padding:0;margin:0;display:block;list-style:none}.filters-field .choice-group-wrapper .choice-group>.items .dropdown>.content>ul>li{display:list-item;margin:0;padding:0}.filters-field .choice-group-wrapper .choice-group>.items .dropdown>.content>ul>li::before,.filters-field .choice-group-wrapper .choice-group>.items .dropdown>.content>ul>li::after{display:none}.filters-field .choice-group-wrapper .choice-group>.items .dropdown>.content>ul>li{padding-top:1.5rem}.filters-field .choice-group-wrapper .choice-group>.items .dropdown>.content .dropdown-block-link{font-size:1.6rem;color:#212121;-webkit-transition:color 0.3s;transition:color 0.3s}.filters-field .choice-group-wrapper .choice-group>.items .dropdown>.content .dropdown-block-link:hover{color:#046b99;cursor:pointer}.filters-field .choice-group-wrapper .choice-group>.items .dropdown>.content .dropdown-block-link.disabled{color:#5b616b}.filters-field .choice-group-wrapper .choice-group>.items .dropdown>.content .dropdown-block-link.disabled:hover{color:#5b616b;cursor:default}@media screen and (max-width:759px){.filters-field .choice-group-wrapper .choice-group>.items .dropdown{margin-top:1rem;width:30rem}}.filters-field .choice-group-wrapper .choice-group>.items .dropdown .content{display:-webkit-box;display:flex;-webkit-box-pack:justify;justify-content:space-between;-webkit-box-orient:horizontal;-webkit-box-direction:normal;flex-direction:row}.filters-field .choice-group-wrapper .choice-group>.items .dropdown .content input{max-width:8rem}.filters-field .choice-group-wrapper .choice-group>.items .dropdown .content input::-webkit-outer-spin-button,.filters-field .choice-group-wrapper .choice-group>.items .dropdown .content input::-webkit-inner-spin-button{-webkit-appearance:none;margin:0}.filters-field .choice-group-wrapper .choice-group>.items .dropdown .content input[type=number]{-moz-appearance:textfield}.filters-field .choice-group-wrapper .choice-group>.items .dropdown .actions-bar{text-align:right}.filters-field .choice-group-wrapper .choice-group>.items .dropdown .actions-bar .apply-btn{margin:0}@media screen and (max-width:480px){.filters-field .choice-group-wrapper .choice-group>.items .dropdown .actions-bar .apply-btn{margin-top:1.5rem}}.filters-field .choice-group-wrapper .choice-group>.items .dropdown .actions-bar .clear-btn{background-color:transparent;display:inline-block;margin:0;padding:1rem 2rem;font-size:1.4rem;font-weight:400;line-height:1.7rem;text-align:center;text-decoration:none;color:#212121;border:1px solid #aeb0b5;-webkit-transition:background-color 0.3s,border-color 0.3s,color 0.3s;transition:background-color 0.3s,border-color 0.3s,color 0.3s;line-height:1.4rem}.filters-field .choice-group-wrapper .choice-group>.items .dropdown .actions-bar .clear-btn:hover{border-color:#046b99;color:#046b99}.filters-field .choice-group-wrapper .choice-group>.items .dropdown .actions-bar .clear-btn:active{color:#ffffff;background-color:#205493;border-color:transparent}.filters-field .choice-group-wrapper .choice-group>.items .dropdown .end-date{margin-top:1.5rem}.filters-field .choice-group-wrapper .choice-group input[type="checkbox"],.filters-field .choice-group-wrapper .choice-group 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0;background-color:transparent;border-top:none;border-bottom:none}}.search-options a{color:#212121;-webkit-transition:color 0.3s;transition:color 0.3s}.search-options a:hover{color:#000000}.search-options .filters-trigger,.search-options .timeline-trigger{width:auto;padding:0;margin:0;background-color:transparent;font-weight:400;-webkit-font-smoothing:initial;color:inherit;line-height:2.1rem;margin:.6rem 0;padding:.4rem 1rem .4rem 3.5rem;position:relative;font-size:1.4rem;background-color:transparent;background-repeat:no-repeat;background-position:left 1rem center}@media screen and (max-width:759px){.search-options .filters-trigger,.search-options .timeline-trigger{float:left;background-position:left .1rem center;padding-left:2.5rem}}@media screen and (min-width:760px){.search-options .filters-trigger,.search-options .timeline-trigger{border:1px solid #aeb0b5;-webkit-transition:border 0.3s,color 0.3s;transition:border 0.3s,color 0.3s}.search-options 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(max-width:759px){.search-options>.inner-wrap{width:auto;margin:0}}.search-options>.inner-wrap::after{content:'';display:block;clear:both;height:0}@media screen and (max-width:759px){.search-options>.inner-wrap{height:4.1rem}}@media screen and (min-width:760px){.search-options>.inner-wrap{display:-webkit-box;display:flex;-webkit-box-orient:horizontal;-webkit-box-direction:normal;flex-flow:row wrap;-webkit-box-pack:justify;justify-content:space-between;-webkit-box-align:center;align-items:center}.search-options>.inner-wrap::after{display:none}}@media screen and (min-width:760px) and (max-width:1019px){.search-options>.inner-wrap{padding-top:1rem;padding-bottom:1rem;border-top:none;height:10.4rem}}@media screen and (min-width:1020px){.search-options>.inner-wrap{width:1020px;padding-left:280px}}@media screen and (min-width:1020px){.search-options .filters{height:0;width:0;position:absolute;display:none}}@media screen and (min-width:760px){.search-options 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.sort-label.has-order{padding-right:3.6rem}@media screen and (max-width:759px){.search-options .result-display .sort-label.has-order{margin-right:-1.2rem}}.search-options .result-display 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screen and (max-width:759px){.search-results-list{background-color:#f1f1f1}.search-results-list.padded-on-mobile,.search-results-list.matching-citations{margin-top:1rem}}@media screen and (min-width:760px){.search-results-list{margin-top:2.4rem}}.search-results-list::after{visibility:hidden;opacity:0;-webkit-transition:opacity 0.3s,visibility 0s linear 0.3s;transition:opacity 0.3s,visibility 0s linear 0.3s;content:'';position:absolute;left:0;right:0;top:0;bottom:0;background-color:rgba(255,255,255,0.8)}.search-results-list.loading::after{-webkit-transition-delay:0s;transition-delay:0s;visibility:visible;opacity:1}.search-results-list>.title{display:none}.search-results-list>.explanation,.search-results-list .altered-search-explanation{display:table;line-height:2rem;padding:0.2rem 1rem;font-size:1.4rem;background-color:#fff1d2;margin-bottom:2rem}@media screen and (max-width:759px){.search-results-list>.explanation,.search-results-list 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url("data:image/svg+xml;base64,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") no-repeat center/2rem;height:1rem;width:2rem;-webkit-transform:rotate(-90deg);transform:rotate(-90deg);margin:0;padding:0;margin-right:1rem}@media screen and (min-width:1020px){.group-titles-container>li>a .category-toggle-icon{display:none}}.group-titles-container .mobile-current-title-link a{font-weight:bold}@media screen and (max-width:1019px){.group-titles-container .mobile-current-title-link a{color:#0071bc}}.group-titles-container .mobile-current-title-link a .category-toggle-icon{-webkit-transform:rotate(90deg);transform:rotate(90deg)}.group-titles-container .desktop-current-title-link{color:#0071bc;font-weight:bold;border-left:5px solid #0071bc}@media screen and (min-width:760px){.static-filters{padding-right:1rem}}@media screen and (min-width:1020px){.static-filters{display:block;float:left;width:260px;padding-left:2rem;position:relative;z-index:1}}.static-filters .side-timeline-filter{margin-bottom:4rem}.static-filters .side-timeline-filter>.title{font-family:BlinkMacSystemFont,-apple-system,"Segoe UI","Roboto","Oxygen","Ubuntu","Cantarell","Fira Sans","Droid Sans","Helvetica Neue",sans-serif;font-weight:300;font-size:1.6rem;text-transform:lowercase;font-variant:small-caps;display:block;line-height:2rem;margin:1rem 0 2rem;color:#757575}.static-filters .side-timeline-filter .toggle-button{top:4rem;width:3.1rem;overflow:hidden;text-indent:-100rem;background:rgba(255,255,255,0.8) url("../../search/images/timeline-filter-toggle.svg") no-repeat -1.3rem center/auto 1.3rem;-webkit-transition:color 0.3s,border-color 0.3s,background-position 0.5s;transition:color 0.3s,border-color 0.3s,background-position 0.5s}.static-filters .side-timeline-filter .toggle-button:hover{background-image:url("../../search/images/timeline-filter-toggle-blue.svg")}.static-filters .side-timeline-filter .reset-button{left:8rem;top:4rem}.static-filters .side-timeline-filter .inner-wrap{width:100%;padding:0 1.4rem;-webkit-transition:width 0.2s;transition:width 0.2s;background-color:rgba(255,255,255,0.9)}.static-filters .side-timeline-filter .slider::before{left:-1.2rem;right:-1.2rem}.static-filters .side-timeline-filter.expanded .inner-wrap{-webkit-transition-duration:0.5s;transition-duration:0.5s;width:98rem}.static-filters .side-timeline-filter.expanded .toggle-button{background-position:0.8rem center}.static-filters .side-timeline-filter.expanded .histogram svg{-webkit-transition-duration:0.5s;transition-duration:0.5s;height:15rem}@media screen and (max-width:1019px){.static-filters .side-timeline-filter{display:none}}.timeline-filter{position:relative}.timeline-filter>.title{display:none}.timeline-filter .toggle-button,.timeline-filter .download-results-by-year-button,.timeline-filter .reset-button{background-color:transparent;display:inline-block;margin:0;padding:1rem 2rem;font-size:1.4rem;font-weight:400;line-height:1.7rem;text-align:center;text-decoration:none;color:#212121;border:1px solid #aeb0b5;-webkit-transition:background-color 0.3s,border-color 0.3s,color 0.3s;transition:background-color 0.3s,border-color 0.3s,color 0.3s;width:auto;padding:0.7rem 1rem;background-color:rgba(255,255,255,0.8);font-size:1.4rem;position:absolute;z-index:1;left:0;top:0}.timeline-filter .toggle-button:hover,.timeline-filter .download-results-by-year-button:hover,.timeline-filter .reset-button:hover{border-color:#046b99;color:#046b99}.timeline-filter .toggle-button:active,.timeline-filter .download-results-by-year-button:active,.timeline-filter .reset-button:active{color:#ffffff;background-color:#205493;border-color:transparent}.timeline-filter .toggle-button:active,.timeline-filter .download-results-by-year-button:active,.timeline-filter .reset-button:active{background-color:rgba(255,255,255,0.8);border-color:#02bfe7;color:#02bfe7}.timeline-filter .toggle-button{display:block}.timeline-filter .export-search-by-year-form{position:absolute}.timeline-filter .download-results-by-year-button{left:4rem;height:3.3rem;width:3.1rem;background:rgba(255,255,255,0.8) url("data:image/svg+xml;base64,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") no-repeat 0.6rem/1.7rem}.timeline-filter .download-results-by-year-button:hover{background-image:url("data:image/svg+xml;base64,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")}.timeline-filter .reset-button{left:8rem;visibility:hidden;opacity:0;-webkit-transition:border-color 0.3s,color 0.3s,opacity 0.3s,visibility 0s linear 0.3s;transition:border-color 0.3s,color 0.3s,opacity 0.3s,visibility 0s linear 0.3s}.timeline-filter .reset-button.active{-webkit-transition-delay:0s;transition-delay:0s;visibility:visible;opacity:1}.timeline-filter .histogram{position:relative}.timeline-filter .histogram svg{width:100%;height:11rem;vertical-align:top;-webkit-transition:height 0.2s;transition:height 0.2s}.timeline-filter .histogram .bar-group{cursor:pointer}.timeline-filter .histogram .bar-group .bar{fill:rgba(0,0,0,0.15);stroke:#ffffff;stroke-width:0.4}.timeline-filter .histogram .bar-group .bar-bg{fill:transparent}.timeline-filter .histogram .bar-group.selected .bar{fill:url("#timeline-filter-selected-gradient")}.timeline-filter .histogram .hint{display:none;position:absolute;top:100%;z-index:10;margin-top:0.9rem;background-color:rgba(33,33,33,0.9);color:#ffffff;padding:0.6rem 1rem;font-size:1.4rem;line-height:2rem;white-space:nowrap;text-align:center;-webkit-transform:translateX(-50%);transform:translateX(-50%)}.timeline-filter .histogram .hint.active{display:block}.timeline-filter .histogram .hint::before{content:'';display:block;width:1rem;height:1rem;position:absolute;left:50%;bottom:100%;background:url("data:image/svg+xml;base64,PHN2ZyB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHdpZHRoPSIxMCIgaGVpZ2h0PSIxMCI+CiAgPHBvbHlnb24gZmlsbD0iIzIxMjEyMSIgcG9pbnRzPSIwLDEwIDUsNSAxMCwxMCIvPgo8L3N2Zz4K") no-repeat center bottom/1rem;opacity:.9;-webkit-transform:translateX(-50%);transform:translateX(-50%)}.timeline-filter .histogram .hint .year::after{content:':'}.timeline-filter .histogram.inactive .hint{display:none}.timeline-filter .histogram:not(.inactive) .bar-group:hover .bar{fill:url("#timeline-filter-hovered-gradient")}.timeline-filter .slider{margin:-0.8rem 0 0;position:relative}.timeline-filter .slider::before{content:'';display:block;position:absolute;left:0;right:0;top:50%;height:0.2rem;background-color:rgba(0,0,0,0.15);-webkit-transform:translateY(-50%);transform:translateY(-50%)}.timeline-filter .slider .noUi-target{margin:0 auto;height:2rem;background-color:transparent;border:none;box-shadow:none}.timeline-filter .slider .noUi-base{height:2rem}.timeline-filter .slider .noUi-connects{overflow:visible}.timeline-filter .slider .noUi-connect{position:absolute;top:50%;height:2rem;margin-top:-1rem;background-color:transparent}.timeline-filter .slider .noUi-connect::after{content:'';display:block;position:absolute;left:0;right:0;top:50%;height:0.2rem;background-color:#1CA186;box-shadow:0 0 0 1px #ffffff;-webkit-transform:translateY(-50%);transform:translateY(-50%)}.timeline-filter .slider .noUi-origin{top:50%}.timeline-filter .slider .noUi-handle{width:2rem;height:2rem;background-color:#ffffff;top:50%;border-radius:100%;border:0.2rem solid #1CA186;box-shadow:0 0 0 0.15rem rgba(255,255,255,0.7);cursor:-webkit-grab;cursor:grab;-webkit-transform:translate(50%,-50%);transform:translate(50%,-50%)}.timeline-filter .slider .noUi-handle:focus{box-shadow:0 0 3px #3E94CF,0 0 7px #3E94CF;outline:none;outline:none}.timeline-filter .slider .noUi-handle::before,.timeline-filter .slider .noUi-handle::after{display:none}.timeline-filter .slider .noUi-handle .noUi-tooltip{bottom:auto;top:100%;border:none;font-size:1.4rem;-webkit-transform:none;transform:none;width:3.4rem;margin-top:0.7rem;margin-left:-1.7rem;margin-bottom:-0.2rem;padding:0;line-height:1;background-color:transparent}.timeline-filter .slider .noUi-handle .noUi-tooltip.with-dash::after{content:'-';position:absolute}.timeline-filter .slider .noUi-handle .noUi-tooltip.hidden{display:none}.timeline-filter .slider .noUi-horizontal .noUi-handle{right:0}.timeline-filter-gradient{display:block;visibility:hidden;position:absolute;left:0;bottom:0;width:1px;height:14rem}.user-filters{padding-bottom:0.9rem}@media screen and (max-width:1019px){.user-filters{display:none;padding-bottom:0}}.user-filters .user-filter-title{display:-webkit-box;display:flex;-webkit-box-align:center;align-items:center}.user-filters .user-filter-title>.title{font-family:BlinkMacSystemFont,-apple-system,"Segoe UI","Roboto","Oxygen","Ubuntu","Cantarell","Fira Sans","Droid Sans","Helvetica Neue",sans-serif;font-weight:300;font-size:1.6rem;text-transform:lowercase;font-variant:small-caps;line-height:2rem;margin:1rem 0 1.5rem;color:#757575}.user-filters .user-filter-title .manage-myncbi-link{height:1.2rem;width:1.2rem;margin-left:1rem;background:url("data:image/svg+xml;base64,PHN2ZyB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHZpZXdCb3g9IjAgMCA2MCA2MCIgd2lkdGg9IjYwcHgiIGhlaWdodD0iNjBweCI+CiAgPHBhdGggZmlsbD0iIzIxMjEyMSIgZD0iTSA1MCw1MCAxMCw1MCAxMCwxMC4xNTYyNSAyMCwxMCAyMCwwIDAsMCAwLDYwIDYwLDYwIDYwLDM1IDUwLDM1IDUwLDUwIFogTSAzMCwwIDQwLDEwIDI0Ljk5OTk5OSwyNSAzNSwzNSA1MCwyMCA2MCwzMCA2MCwwIDMwLDAgWiIgLz4KPC9zdmc+Cg==") no-repeat left center;background-size:1.2rem;margin-bottom:0.4rem}.user-filters .user-filter-items{padding:0;margin:0;display:block;list-style:none}.user-filters .user-filter-items>li{display:list-item;margin:0;padding:0}.user-filters .user-filter-items>li::before,.user-filters .user-filter-items>li::after{display:none}.user-filters .user-filter-items .user-filter-link{margin-bottom:1rem}.user-filters .user-filter-items .user-filter-link:visited{color:#0071bc}.user-filters .user-filter-items .user-filter-link.empty-filter{color:#5b616b}.user-filters .user-filter-items .user-filter-link.current-filter{display:block;width:auto;color:#000000;background-color:rgba(0,0,0,0.05);margin:0;font-weight:bold;padding-left:1rem;border-left:3px solid #0071bc}.user-filters .user-filter-show-toggle-wrap{width:100%;height:3rem;margin-bottom:2rem}.user-filters .user-filter-show-toggle-wrap .user-filter-show-toggle{display:inline-block;width:auto;line-height:2.4rem;font-weight:normal;text-transform:lowercase;text-decoration:none;color:#323a45;background-color:#ffffff;border-radius:3px;margin:0;padding:0 1rem;-webkit-transition:color 0.3s,background-color 0.3s;transition:color 0.3s,background-color 0.3s;position:relative;padding-left:2.5rem;height:2.4rem;margin-top:auto;margin-bottom:1.2rem;float:right;padding-bottom:0.05rem}.user-filters .user-filter-show-toggle-wrap .user-filter-show-toggle:hover,.user-filters .user-filter-show-toggle-wrap .user-filter-show-toggle:visited{color:#1d2127;background-color:#e6e6e6}.user-filters .user-filter-show-toggle-wrap .user-filter-show-toggle::before{content:'';display:block;position:absolute;left:.5rem;top:.6rem;width:1.5rem;height:1.5rem;background:url("data:image/svg+xml;base64,PHN2ZyB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHdpZHRoPSI0OCIgaGVpZ2h0PSI0OCIgdmlld0JveD0iMCAwIDQ4IDQ4Ij4KIDxwYXRoIHN0eWxlPSJmaWxsLW9wYWNpdHk6IDAuNyIgZD0ibTQyIDI3IHYtNiBoLTE1IHYtMTUgaC02IHYxNSBoLTE1IHY2IGgxNSB2MTUgaDYgdi0xNSB6Ii8+Cjwvc3ZnPgo=") no-repeat left 0/1.5rem}.user-filters .user-filter-show-toggle-wrap .user-filter-show-toggle.active::before{background-image:url("data:image/svg+xml;base64,PHN2ZyB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHdpZHRoPSI0OCIgaGVpZ2h0PSI0OCIgdmlld0JveD0iMCAwIDQ4IDQ4Ij4KIDxwYXRoIHN0eWxlPSJmaWxsLW9wYWNpdHk6IDAuNyIgZD0ibTQwIDI3IHYtNiBoLTMyIHY2IHoiLz4KPC9zdmc+Cg==")}.overlay .citation-dialog{padding:0;min-height:initial}.overlay .citation-dialog .close-overlay{top:1rem;right:1rem}.overlay .citation-dialog>.title{font-family:BlinkMacSystemFont,-apple-system,"Segoe UI","Roboto","Oxygen","Ubuntu","Cantarell","Fira Sans","Droid Sans","Helvetica Neue",sans-serif;font-weight:300;font-size:1.6rem;text-transform:lowercase;font-variant:small-caps;font-size:1.9rem;line-height:2rem;margin-bottom:0;padding:1rem 2rem}@media screen and (max-width:375px){.overlay .citation-dialog>.title{font-size:1.6rem}}.overlay .citation-dialog .citation-text-block{padding:2rem 2rem 0.7rem;position:relative}.overlay .citation-dialog .citation-text-block .citation-actions{display:-webkit-box;display:flex;-webkit-box-pack:justify;justify-content:space-between;padding-bottom:.5rem}.overlay .citation-dialog .citation-text-block .copy-button{background-color:transparent;display:inline-block;margin:0;padding:1rem 2rem;font-size:1.4rem;font-weight:400;line-height:1.7rem;text-align:center;text-decoration:none;color:#212121;border:1px solid #aeb0b5;-webkit-transition:background-color 0.3s,border-color 0.3s,color 0.3s;transition:background-color 0.3s,border-color 0.3s,color 0.3s;font-size:1.6rem;position:relative;border:none;padding-left:2rem;padding-right:.5rem;margin-right:.5rem;color:#5b616b;height:4.2rem;line-height:2.4rem;margin-right:1rem;padding:0 .5rem 0 2.5rem;color:#000000;width:auto}.overlay .citation-dialog .citation-text-block .copy-button:hover{border-color:#046b99;color:#046b99}.overlay .citation-dialog .citation-text-block .copy-button:active{color:#ffffff;background-color:#205493;border-color:transparent}.overlay .citation-dialog .citation-text-block .copy-button::before{position:absolute;top:50%;-webkit-transform:translateY(-50%);transform:translateY(-50%);content:'';display:block;width:2rem;height:2rem;background:url("data:image/svg+xml;base64,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") no-repeat center/1.4rem;left:0;background-position:left center}.overlay .citation-dialog .citation-text-block .copy-button:active{background-color:transparent;color:#046b99}.overlay .citation-dialog .citation-text-block .copy-button:active::before{-webkit-filter:none;filter:none}.overlay .citation-dialog .citation-text-block .copy-button:active,.overlay .citation-dialog .citation-text-block .copy-button:hover{-webkit-filter:brightness(0) saturate(100%) invert(23%) sepia(41%) saturate(4411%) hue-rotate(180deg) brightness(95%) contrast(97%);filter:brightness(0) saturate(100%) invert(23%) sepia(41%) saturate(4411%) hue-rotate(180deg) brightness(95%) contrast(97%)}.overlay .citation-dialog .citation-text-block .copy-button::before{background-size:1.8rem;width:2.5rem;height:4.2rem;background-position:left center}.overlay .citation-dialog .citation-text-block .copy-button::before{width:2.5rem;height:2.5rem}.overlay .citation-dialog .citation-text-block .copy-button.disabled{opacity:.7}.overlay .citation-dialog .citation-text-block 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.permalink-copy-button>.button-title{padding-left:1.5rem}.overlay .share-dialog .content 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